Bills storyline to watch: Scoring points on the road hasn’t been a strong point for the Bills, who are averaging 21 points in the four games away from Orchard Park, New York, this season (2-2 in those games). There will be an opportunity to amend that against a Seahawks defense that has allowed 23.4 points per game (19th) this year. The offense will be assisted by WR Amari Cooper playing in his second game with the Bills. — Alaina Getzenberg
Seahawks storyline to watch: After allowing the fifth-most rushing yards per game (146.1) through Week 7, the Seahawks are hoping their trade for LB Ernest Jones IV will help one of the league’s worst run defenses. Jones, who’s sliding into the middle linebacker spot in coach Mike Macdonald’s defense, will face the Bills for the second week in a row. He recorded five tackles, a QB hit and a pass defensed for the Titans in their loss to Buffalo last Sunday. — Brady Henderson
Stat to know: If the Seahawks score over 20 points for the eighth straight game, they’ll tie the longest streak of reaching that mark to begin a season in franchise history (2020).
Bold prediction: Bills TE Dalton Kincaid will record six or more receptions. Seahawks CB Riq Woolen has a 9% target rate allowed this season, per NFL Next Gen Stats, which should funnel targets away from outside receivers. That could mean more targets for Kincaid, who would also see some snaps against Jones in his first game with the Seahawks. — Walder
Fantasy X factor: Cooper. He was eased into action in Week 7, playing just 35% of snaps. Cooper had five targets and finished with 16.6 fantasy points despite a limited role. Cooper could be a game-changer for the rest of the season and has WR1 potential catching passes from QB Josh Allen. See Week 8 rankings. — Moody
Betting nugget: The Seahawks are 17-7 ATS as home underdogs since 2011, including 4-3 ATS in QB Geno Smith starts.
Kahler’s pick: Bills 24, Seahawks 22
Moody’s pick: Bills 28, Seahawks 27
Walder’s pick: Bills 24, Seahawks 21
FPI prediction: BUF, 63.8% (by an average of 5.0 points)