Chiefs storyline to watch: In seven career games against the Chiefs, counting three in the playoffs, quarterback Josh Allen has 16 touchdown passes, three interceptions and a QBR of 74. Are the Chiefs capable of keeping him from another big game this time, even if Allen is throwing to a group of receivers depleted by injuries? In the past two weeks, the Chiefs put up little resistance against Tampa Bay’s Baker Mayfield and Denver’s Bo Nix. — Adam Teicher
Bills storyline to watch: Can the Bills’ defense continue to limit the Chiefs’ offense in the regular season? The Bills have held the Chiefs to 20.8 points per game in four regular-season meetings since 2020. Taking the ball away is a point of emphasis for this defense and could be the key to success. The Bills have 12 straight games with at least one takeaway, the second-longest active streak in the NFL after the Lions (13). — Alaina Getzenberg
Stat to know: The Bills have won five straight games; Buffalo’s plus-61 scoring margin during the win streak is the third highest by any team in the NFL over that span, trailing only the Lions (plus-91) and the Eagles (plus-82)
Bold prediction: Bills cornerback Christian Benford will pick off quarterback Patrick Mahomes. Benford is playing great this season. In fact, no outside cornerback has allowed fewer yards per coverage snap (0.6) than him, per NFL Next Gen Stats. Part of that is because he’s allowing fewer targets than average (13%) but also that he has a minus-9% completion percentage allowed over expectation. — Walder
Fantasy X factor: Chiefs running back Kareem Hunt. Kansas City is first in time of possession (33:01), which means we should see a lot of Hunt. He has had 20-plus touches in each of his past four games, scoring at least 17 fantasy points in three of them. The Bills’ defense is allowing the second-most fantasy points per game to running backs. See Week 11 rankings. — Moody
Betting nugget: The Chiefs are 0-4 ATS in their past four conference games.
Kahler’s pick: Bills 29, Chiefs 27
Moody’s pick: Bills 25, Chiefs 23
Walder’s pick: Bills 24, Chiefs 17
FPI prediction: BUF, 53.1% (by an average of 1.4 points)
